New pathway for the synthesis of sinapoyl malate, of sinapine and of analogues thereof, and use thereof as antimicrobial molecules
The invention relates to anti-UV molecules of natural origin, and to the process for the synthesis thereof and also the process for the synthesis of analogues thereof. More particularly, it relates to a two-step process for the synthesis of sinapoyl malate, of sinapine and of analogues and derivatives thereof; this process is faster and more ecological than the prior art processes. The molecules obtained by means of this process are water-soluble.
Synthesis of Meldrum Acid derivatives presenting anti-UVA and blue light, anti-pigmenting and/or antioxidant activities
The invention relates to the field of molecules exhibiting anti-UV and anti-pigmenting properties. More particularly, the invention relates to the use of derivatives of Meldrum's acid exhibiting anti-UVA and blue light, anti-pigmenting and / or anti-oxidant and protective activities against the cold, used alone or as a mixture as as UV filter and / or blue light. These compounds can be used in many fields of application such as cosmetics, in particular sunscreens, food, pharmaceuticals, polymers, biocontrol and protection of plants against the cold.
Method for purifying high molecular weight adenosine-based coenzymes by tangential diafiltration
The present invention relates to the field of making high molecular weight adenosine-based coenzymes available on a large scale. In particular, it relates to a method for purifying high molecular weight adenosine-based coenzymes by implementing a tangential diafiltration, or even dia-ultrafiltration step. This method is, for example, applicable to the purification of coenzyme A disulfide ((CoAS)2), coenzyme A (CoA), nicotinamide adenine dinucleotide (NAD+), nicotinamide adenine dinucleotide phosphate (NADP+) or flavin adenine dinucleotide (FAD).
Shape Memory Polymer Based on Poly(Hydroxyalkanoates)
The invention relates to the field of shape memory polymers. More particularly, the invention relates to polymers based on poly (hydroxyalkanoates) (PHA) and on copolymers with improved elastomeric properties. They are used as a protective, reinforcing, covering or embellishing material having mechanical properties allowing a substitution for materials based on technical polymers such as plasticized PVCs, polyolefins, polyesters, polyurethanes and polyamides.
Biocatalytic method for producing 2H-HBO and β-substituted analogues from LGO using a cyclohexanone monooxygenase
The invention relates to the field of producing 4-hydroxymethyl-γ-butyrolactone (2H-HBO) from levoglucosenone (LGO). More particularly, the invention concerns an eco-compatible method for synthesising 2H-HBO optionally substituted at the β-position of the lactone function from LGO or a saturated form of LGO such as dihydrolevoglucosenone (2H-LGO) or LGO hydrate (OH-LGO) via a biocatalytic reaction using a cyclohexanone monooxygenase (CHMO).
Catalytic synthesis of anti-UV and antioxidant conjugated 8-8 dimers in a green solvent
The invention relates to biobased anti-UV molecules. In particular, the invention relates to a novel process for preparing b-b dimers having anti-UV and antioxidant properties, from p-hydroxycinnamic esters and amides disubstituted in the ortho position with respect to the phenol function and from ketones disubstituted in the ortho position with respect to the phenol, in particular from sinapic acid esters and amides and ketone analogues. The dimers of formulae (I), (II), (III) and (IV) as obtained by means of the process according to the invention can be used for the production of polymers/plastics (in plastics technology), for the protection of plants against the cold and as cosmetic or food-processing ingredients.
Materials and methods for alkene reduction of levoglucosenone by an alkene reducatase
The subject invention concerns materials and methods for alkene reduction of compounds, such as levoglucosenone (LGO) and (S)-γ-hydroxymethyl-α,β-butenolide (HBO), using an alkene reductase enzyme. In one embodiment, a method of the invention comprises alkene reduction of a target compound by reacting the compound with an Old Yellow Enzyme (OYE) that reduces alkene bonds. In one embodiment, the OYE is OYE 2.6 from Pichia stipites and comprises the amino acid sequence of SEQ ID NO:1.
In a specific embodiment, the enzyme is an Old Yellow Enzyme (OYE) 2.6 mutant having an amino acid substitution at position Q 78 in the sequence, wherein the tyrosine at position 78 is substituted with a tryptophan amino acid (Y78W) and is designated as OYE 2.6 Y78W (SEQ ID NO:2).
Electronic bee smoker
The invention concerns a bee smoker characterised in that it comprises an enclosure inside which there is arranged an interchangeable cartridge containing a non-glycol active composition, in liquid phase that can be volatilised, said enclosure opening into a smoking duct and having an inlet for a pulsed air flow produced by an air flow generator the bee smoker comprising a means for vaporising said active composition without the combustion of said composition. The invention also concerns an active composition intended for smoking bees containing at least 15% triethyl citrate.
Method for converting levoglucosenone into 4-hydroxymethyl butyrolactone and 4-hydroxymethyl butenolide without using any organic solvent and catalyst.
The invention relates to a method for converting levoglucosenone into 4-hydroxymethyl butyrolactone and 4-hydroxymethyl butenolide without using any solvent or catalyst, wherein the oxidation and hydrolysis of the levoglucosenone or hydrogenated levoglucosenone are carried out in a single step using an aqueous solution of H2O2.
Method for synthesizing a precursor of a single dairy-lactone isomer.
The present invention relates to a method for preparing a precursor of a single dairy-lactone isomer, to a single dairy-lactone isomer, and to the organoleptic uses thereof.
Phenol polymer with 5,5'-biaryl bonds, method for preparing same, and uses thereof
The invention relates to a phenol polymer obtainable by oligomerization of one or more macropolyphenols serving as monomers, wherein the oligomerization is catalyzed by an oxidase enzyme. The bonds between the macropolyphenol fragments in said polymer are exclusively 5,5'-biaryl bonds. This polymer is useful as an antioxydant, chelating agent, plasticizing agent, or antimicrobial agent.
Process for levoglucosenone transformation to 4-hydroxymethylbutyrolactone and 4-hydroxymethylbutenolide
Our second patent has been lodged! This patent is related to the transformation of levoglucosenone into platform chemicals. These molecules are intended to be building blocks for food/feed, polymers and pharmaceutical industries. If you are interested in this technology please contact our business development team for further information.
Process for the preparation and utilisation of phenolic polymers with biaryl 5-5 bonds.
Our first patent approval rewards the tremendous work of our team on lignin (bio)transformation. It is related to the preparation and utilisation of polyphenols with exclusively biaryl bonds. Obtained through biocatalysed oligomerisation of 100% renewable monomers, these polyphenols exhibit antioxidant, antiradical and antimicrobial properties. Furthermore, these polymers are good plasticizers, allowing them to be considered as attractive bisphenol A substitutes.
These polyphenols are 100% bio-based and non toxic, as a consequence, they are suitable for applications in the food and cosmetic industries. If you want to know more about this patent and possible applications please contact our business development team.